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Daptomycin, Fosomycin, Or Both For Treatment Of Me Essay

  • Submitted by: Onitsukatiger
  • on December 5, 2011
  • Category: Miscellaneous
  • Length: 351 words

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Below is an essay on "Daptomycin, Fosomycin, Or Both For Treatment Of Me" from Anti Essays, your source for research papers, essays, and term paper examples.

The emergence of glycopeptides tolerance and resistance to vancomycin represents a major concern in the treatment of deep-seated infections, including osteomyelitis, since those drugs have been the reference standard therapy for complicated methicillin-resistant Staphylococcus aureus (MRSA) infections for decades. Data on the combination of (Daptomycin) DAP and (Fosomycin) FOF are limited, and little is known about ots effectiveness on osteomyelitis. The authors aim to evaluate the efficacy of such treatment. The in vivo activities of daptomycin, fosfomycin, and a combination of both antibiotics against a clinical isolate of methicillin-resistant Staphylococcus aureus (daptomycin MIC, 0.25 μg/ml; fosfomycin MIC, 0.5 μg/ml were evaluated in a rat model of chronic MRSA osteomyelitis. A total of 37 rats with experimental osteomyelitis were treated for 4 weeks with either 60 mg/kg of body weight of daptomycin subcutaneously once daily, 75mg/kg fosfomycin intraperitoneally once daily, a combination of both drugs, or a saline placebo. As the results, bone cultures were found to be positive for methicillin-resistant S. aureus in 9 of 9 (100%) animals of the placebo group, in 9 of 9 (100%) animals treated with daptomycin, in 1 of 10 (10%) fosfomycin-treated rats, and in 1 of 9 (22.2%) rats comprising the combination group. Results of bacterial counts in the bone samples were expressed as log10 CFU/g bone and analyzed by using Mann-Whitney U test followed by Bonferroni’s multiple-comparison test. The authors conclude treatment with daptomycin was significantly superior to placebo, although it remained inferior to treatment with fosfomycin. The authors add that no synergistic or antagonistic effect was observed for the combination theraphy. Last the authors conclude there is no development of resistance against daptomycin of fosfomycin was observed after the 4-week treatment period. This article has complete explanation in all method, results and discussion section. Although...

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